This disturbing question has been on the minds of many scientists recently, thanks to a pair of controversial experiments in which the h5n1 bird flu virus was transformed into mutant forms that. Freeze on mutant-flu research set to thaw : nature news & comment 6/27/12 2:00 pm page 3 of 4. Virus metagenomics is a young research filed but it has already transformed our understanding of virus diversity and evolution, and illuminated at a new level the connections between virus.
A recent history of mutant viruses if you read up on your mutant virus research—it's ok, we'll summarize—you'll see one name come up over and over again: yoshihiro kawaoka, a professor at. Mutation research - genetic toxicology and environmental mutagenesis is now accepting submissions for a new section of the journal that will be dedicated to the discussion of current issues relating to design, interpretation and strategic use of genotoxicity tests (current topics in genotoxicity testing) this section is envisaged to include. Hidden somewhere deep within the tech savvy recesses of a top secret lab, a number of scientists are busy creating a mutant flu virus it is dangerous work, as the authorities have reportedly admitted to its lethal attributes. Recent virus research articles genetic fusion of peste des petits ruminants virus haemagglutinin and fusion protein domains to the amino terminal subunit of glycoprotein b of bovine herpesvirus 1 interferes with transport and function of gb for bhv-1 infectious replication.
To the editor: the pathogenic role of precore mutant in chronic hepatitis b virus (hbv) remains controversial (1, 2)in the recent issue of this journal, maruyama et al compared the severity of. The mutant virus mu-3 was isolated from the soluble receptor-resistant mutant 7 virus (srr7), which is a neuropathogenic strain of the mouse hepatitis virus jhmv, and cloned as a soluble receptor. Fulminant hepatitis b is a rare expression of hbv infection but carries a high mortality 1, 2 coinfection or superinfection with hepatitis d virus often contributes to a poor prognosis 1. An ebv mutant deleted for the ebna3b protein was previously shown to produce lymphomas with decreased t-cell infiltration (in comparison to wt virus) in humanized mice, possibly due to decreased expression of the t-cell chemokine, ip10, in b cells infected with this virus.
Governance of dual-use research: an ethical dilemma michael j selgelid a a centre for applied philosophy and public ethics (cappe), the australian national university, canberra, act, australia. The study is the first to show how vital insecticide-resistance monitoring is to control the aedes mosquito -- which carries the viruses that cause zika, dengue fever and yellow fever. A mutant h3n2 influenza virus uses an alternative activation mechanism in tmprss2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region. Researchers studying a potentially more lethal, airborne version of the bird flu virus have suspended their studies because of concerns the mutant virus they have created could be used as a. Virus suspensions of the wt (lot rsv b1) and cp-52 mutant (lot rsv b-10) were grown in vero cell culture and were found to be free of adventitious agents by louis potash (dyncorp/pri, rockville, md) the titers of the wt rsv b1 strain and rsv b1 cp -52 were 10 50 and 10 55 pfu/ml, respectively.
The gene for enhanced green fluorescent protein (egfp) was inserted into the tk locus of a vgf− vaccinia virus by homologous recombination creating a double-deleted mutant vaccinia virus (vvdd-gfp. It applies to research on 15 deadly pathogens that include highly infectious h5n1, ebola virus and others, as well as seven categories of experiments that make a germ or toxin more lethal. Viruses, an international, peer-reviewed open access journal cutthroat trout virus (ctv) is a non-pathogenic fish virus belonging to the hepeviridae family, and it is distantly related to hepatitis e virus (hev) here, we report the development of an efficient cell culture system where ctv can consistently replicate to titers never observed before with a hepevirus.
The research published last week, led by ron fouchier at the erasmus medical centre in rotterdam, the netherlands, showed that introducing as few as five genetic mutations made the h5n1 virus. Hepatitis b viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options mutations that occur within the immunodominant epitopes of hepatitis b surface antigen (hbsag) allow mutant virus to propagate in the presence of a neutralizing immune. Public health experts have warned that controversial experiments on mutant viruses could put human lives in danger by unleashing an accidental pandemic several groups of scientists around the.
News science exclusive: controversial us scientist creates deadly new flu strain for pandemic research scientists express horror over the creation of a virus that could render the human immune. The national institutes of health has lifted a ban on “gain-of-function” research on tuesday—the kind of research that requires genetically modifying viruses to make them more deadly or more. Genetic engineering, also called genetic modification or genetic manipulation, is the direct manipulation of an organism's genes using biotechnologyit is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organismsnew dna is obtained by either isolating and copying the genetic.